Wang Lab











B. Chou, P. Mirau. T. Jiang., S.-W. Wang, K.J. Shea. "Hydrogel Affinity Reagents for Molecules with Lipid-Like Domains." Biomacromolecules, 2016. DOI: 10.1021/acs.biomac.6b00296.

N.M. Molino, M. Neek, J.A. Tucker, E.L. Nelson, S.-W. Wang. "Viral-Mimicking Protein Nanoparticle Vaccine for Eliciting Anti-tumor Responses." Biomaterials. 86:83-91 (2016).

Q. Chen, Q. Sun, N.M. Molino, S.-W. Wang, E.T. Boder, W. Chen. "Sortase-A mediated Multi-functionalization of Protein Nanoparticles." Chemical Communications. 51:12107-12110 (2015).

R. Que, S.W.P. Chan, A. Jabaiah, R.H. Lathrop, N.A. Da Silva, and S.-W. Wang. "Tuning Cellular Response by Modular Design of Bioactive Domains in Collagen." Biomaterials. 53:309-317 (2015).

R. Que, A. Mohraz, N. Da Silva, S.-W. Wang. "Expanding Functionality of Recombinant Human Collagen Through Engineered Non-Native Cysteines." Biomacromolecules. 15:3540-3549 (2014). DOI 10.1021/bm500735d.

Y.K. Kim, R. Que, S.-W. Wang, W. Liu. "Modification of Biomaterials with a Self Protein Inhibits the Macrophage Response." Advanced Healthcare Materials. 3(7):989-994 (2014).

N.M. Molino, S.-W. Wang. "Caged Protein Nanoparticles for Drug Delivery." Current Opinion in Biotechnology. 28:75-82 (2014). Invited contribution for thematic issue on "Nanobiotechnology."

A. Jabaiah, X. Wang, S. K. Raman, R. Ragan, N.A. Da Silva, S.-W. Wang.  "Nanoscale Architecture and Cellular Adhesion of Biomimetic Collagen Substrates."  Journal of Biomaterials Applications. 28(9):1354-1365 (2014).

D. Ren, F. Kratz, S.-W. Wang.  "Engineered drug-protein nanoparticle complexes for folate receptor targeting."  Biochemical Engineering Journal. 89:33-41 (2014).
Invited contribution for special issue on "Bionanofabrication."

N.M. Molino, A.K.L. Anderson, E.L. Nelson, S.-W. Wang.  "Biomimetic Protein Nanoparticles Facilitate Enhanced Dendritic Cell Activation and Cross-Presentation”  ACS Nano. 7:9743-9752 (2013).

S.W.P. Chan, J. Greaves, N. Da Silva, S.-W. Wang.  “Assaying Proline Hydroxylation in Recombinant Collagen Variants by Liquid Chromatography-Mass Spectrometry,” BMC Biotechnology. 12:51 (2012).  DOI: 10.1186/1472-6750-12-51

D. Ren, M. Dalmau, A. Randall, M.M. Shindel, P. Baldi, S.-W. Wang. "Biomimetic Design of Protein Nano-Carriers for Hydrophobic Molecular Transport." Advanced Functional Materials. 22:3170-3180 (2012).   Highlighted in Materials Views ( on April 24, 2012)

M.M. Shindel, S.-W. Wang, A. Mohraz. "Interfacial Polymer Phase Segregation and Self-Assembly of Square Colloidal Crystals." Soft Matter. 8:6684-6688 (2012).

X. Wang, M. Shindel, S.-W. Wang, R. Ragan. "Elucidating Driving Forces for Liposome Rupture: External Perturbations and Chemical Affinity." Langmuir. 28:7417-7427 (2012).

N.M. Molino, K. Bilotkach, D.A. Fraser, D. Ren, S.-W. Wang.  “Complement Activation and Cell Uptake Responses Toward Polymer-Functionalized Protein Nanocapsules.” Biomacromolecules. 13(4):974-981 (2012)

M. Shindel, D. Mumm, S.-W. Wang. “Manipulating Energy Landscapes to Tune Ordering in Biotemplated Nanoparticle Arrays .”  Langmuir. 27(12):7768-7775 (2011).

D. Ren, F. Kratz, S.-W. Wang.  “Protein Nanocapsules Containing Doxorubicin as a pH-Responsive Delivery System.” Small. 7(8):1051-1060 (2011).

X. Wang, M. Shindel, S.-W. Wang, R. Ragan.  “A Facile Approach for Assembling Lipid Bilayer Membranes on Template-Stripped Gold,” Langmuir. 26(23):18239-18245 (2010).

S.W.P. Chan, S.-P. Hung, S. Raman, G.W. Hatfield, R. Lathrop, N. A. Da Silva., S.-W. Wang. "Recombinant Human Collagen and Biomimetic Variants Using a De Novo Gene Optimized for Modular Assembly." Biomacromolecules. 11(6):1460-1469 (2010).

M. Shindel, D. Mumm, S.-W. Wang. “Biotemplating of Metallic Nanoparticle Arrays Through Site-Specific Electrostatic Adsorption on Streptavidin Crystal .”  Langmuir. 26(11):11103-11112 (2010).

M. Dalmau, S. Lim, S.-W. Wang. “pH-Triggered Disassembly in a Caged Protein Complex .”  Biomacromolecules. 10(12):3199-3206 (2009). Featured in "Research Highlights" of Biopolymers (Vol. 93, no. 2, 2010)

M. Dalmau, S. Lim, S.-W. Wang. “Design of a pH-Dependent Molecular Switch in a Caged Protein Platform.”  Nano Letters. 9(1):160-166 (2009).

M. Shindel, A. Mohraz, D. Mumm, S.-W. Wang. “Modulating Colloidal Adsorption on a Two-Dimensional Protein Crystal.”  Langmuir. 25(2):1038-1046 (2009).

M. Dalmau, S. Lim, H. C. Chen, C. Ruiz, S.-W. Wang. “Thermostability and Molecular Encapsulation within an Engineered Caged Protein Scaffold.”  Biotechnology and Bioengineering. 101(4):654-664 (2008). Highlighted in B&B's "Spotlight" Feature and in December 2008 cover photo.

C. Lou, M. Shindel, L. Graham, S.-W. Wang. “Molecular Self-Assembly of Solid-Supported Protein Crystals.”  Langmuir. 24(15):8111-8118 (2008).

C. Lou, Z. Wang, S.-W. Wang. “Two-Dimensional Protein Crystals on a Solid Substrate: Effect of Surface Ligand Concentration.”  Langmuir. 23(19):9752-9759 (2007).

S.-W. Wang, J. Monagle, C. McNulty, D. Putnam, H. Chen. “Determination of P-glycoprotein Inhibition by Excipients and Their Combinations Using an Integrated High-Throughput Process.”  Journal of Pharmaceutical Sciences. 93(11):2755-2767 (2004).

C.R. Gardner, O. Almarsson, H. Chen, S. Morissette, M. Peterson, Z. Zhang, S. Wang, A. Lemmo, J. Gonzalez-Zugasti, J. Monagle, J. Marchionna, S. Ellis, C. McNulty, A. Johnson, D. Levinson, M. Cima. “Application of High Throughput Technologies to Drug Substance and Drug Product Development.”  Computers and Chemical Engineering. 28:943-953 (2004).

S.J. Farah, S.-W. Wang, W.-H. Chang, C.R. Robertson, A.P. Gast.  “Point-Mutagenesis and Cocrystallization of Wild-Type and Mutant Proteins:  A Study of Solid-Phase Coexistence in Two-Dimensional Protein Arrays.”  Langmuir. 17(19):5731-5735 (2001).

S.-W. Wang, C.R. Robertson, A.P. Gast, S. Koppenol, T. Edwards, V. Vogel, P. Stayton.  “Role of N- and C-Terminal Amino Acids in 2D Streptavidin Crystal Formation.” Langmuir.  16(11):5199-5204 (2000).

S.-W. Wang, C.R. Robertson, A.P. Gast.  “Two-Dimensional Crystallization of Streptavidin Mutants.” The Journal of Physical Chemistry B. 103(37):7751-7761 (1999). (Invited feature article & Cover Picture)

S.-W. Wang, C.R. Robertson, A. P. Gast.  “Molecular Arrangement in Two-Dimensional Streptavidin Crystals.” Langmuir. 15(4):1541-1548 (1999).

A. P. Gast, C. R. Robertson, S.-W. Wang, M. T. Yatcilla.  “Two-Dimensional Streptavidin Crystals:  Macropatterns and Micro-organization.”  Biomolecular Engineering. 16(1-4): 21-27 (1999).

S.-W. Wang, C.L. Poglitsch, M.T. Yatcilla, C.R. Robertson, A.P. Gast.  “Solid-Phase Coexistence in Chiral Domains of 2D Streptavidin Crystals.” Langmuir. 13(22):5794-5798 (1997). (Cover Picture)

C. Khosla, R. Caren, C.M. Kao, R. McDaniel, S.-W. Wang.  “Evolutionally Guided Enzyme Design.”  Biotechnology and Bioengineering. 52(1):122-128 (1996).


S.-W. Wang, with N.A. Da Silva, S.-P. Hung, R.H. Lathrop. "Collagen-Like Polypeptides and Encoding Polynucleotides ." Patent pending. Application No. 61/054113, US Patent & Trademark Office (2008).

S.-W. Wang, with H. Chen, Z. Zhang. “Oral Pharmaceutical Formulations Comprising Paclitaxel, Derivatives and Methods of Administration Thereof.”  Patent pending.  Application #20040092428, US Patent & Trademark Office (2004).

S.-W. Wang, with S. Bernstein, H. Chen, C. Gardner, M. O’Brien LeMott.  “Pharmaceutical Formulations of Celecoxib.”  Patent pending.  Application #WO 2004/047752, World Intellectual Property Organization (PCT) (2003).

S.-W. Wang, with H. Chen, Z. Zhang.  “Oral Pharmaceutical Formulations Comprising Paclitaxel, Derivatives and Methods of Administration Thereof.”  Patent pending.  Application #WO 03/045357, World Intellectual Property Organization (PCT) (2003).
University of California, Irvine