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One of the current challenges in biomaterials research is the design and fabrication of functional nanostructures at progressively smaller length scales. Defining architectures at such small dimensions enables the ability to control bulk material properties as well as specific interactions at cell-biomaterial interfaces. Biology has been enormously successful in assembling very complex nanoscale systems, and the general strategy in our laboratory leverages this ability by coupling nature-inspired macromolecular systems with the tools of molecular biology and chemistry. We use the detailed control that genetic engineering provides in defining the polymeric architecture of proteins together with synthetic approaches that broaden the scope of chemical functionality. This enables a better understanding of the relationship between molecular organization and material characteristics, which can then be used towards designing new material properties. Such an approach will ultimately allow us to design new materials and therapeutic strategies. Our research group is currently investigating several areas that have technological relevance in pharmaceutics, tissue engineering, biosensors, and electronic and optical devices. Announcement2007 Spring Da Silva/Wang Joint Group Meeting Schedule
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